کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10587666 981431 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anticancer activities of an antimicrobial peptide derivative of Ixosin-B amide
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Anticancer activities of an antimicrobial peptide derivative of Ixosin-B amide
چکیده انگلیسی
Two potent antimicrobial peptides (AMPs), KWLRRVWRWWR-amide (MAP-04-03) and KRLRRVWRRWR-amide (MAP-04-04), which were derived from a derivative of Ixosin-B-amide (KSDVRRWRSRY), were investigated for their anticancer activities. MAP-04-03 and MAP-04-04 were designed, characterized, and assayed for their effects on the viability of MCF-7 breast cancer cells by the antiproliferative assay. Effects of peptide on cancer cell migration and on the cytoskeleton alteration and cell morphology were analyzed by the wound-healing assay and confocal microscopy. Results indicated that MAP-04-03 not only exhibited inhibitory effects on the proliferation (IC50 = 61.5 μM) and on the cell migration of cancer cells (at a concentration of 5 μM), but also affected the cytoskeleton at the concentration of 25 μM. Results demonstrate it is a promising candidate for further development of anticancer agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 20, 15 October 2013, Pages 5744-5747
نویسندگان
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