3H-1,2,4-Dithiazol-3-one compounds as novel potential affordable antitubercular agents

The readily available 3H-1,2,4-dithiazol-3-one molecule compound 4n was shown to be potent against the virulent Mycobacterium tuberculosis H37Rv strain by a microdilution method, demonstrating a better safety profile on human normal liver L02 cells than the lead compound HT1171, which was reported as a potent proteasome inhibitor of Mycobacterium bovis var. bacilli Calmette-Guérin (BCG).