کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10588245 | 981449 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines Design, solvent free synthesis, and antimicrobial evaluation of 1,4 dihydropyridines](/preview/png/10588245.png)
چکیده انگلیسی
Here in, we report the usage of cellulose sulfuric acid as a heterogeneous eco friendly catalyst for the synthesis of 1,4 dihydropyridines under solvent free conditions via Hantzsch three component reaction of an aldehyde, ethyl acetoacetate and ammonium acetate at 100 °C for 2-5 h. In silico studies were performed on twenty two possible 1,4 dihydropyridines (DHPs) analogues against K+ channel receptor (KcsA). In order to validate in silico studies, thirteen compounds were synthesized and evaluated as antibacterials against twenty seven ESBL isolates of Klebsiella pneumoniae and Escherichia coli.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 18, 15 September 2012, Pages 6016-6023
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 18, 15 September 2012, Pages 6016-6023
نویسندگان
Y.L.N. Murthy, Abdul Rajack, M. Taraka Ramji, J. Jeson babu, Ch. Praveen, K. Aruna Lakshmi,