کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10588314 981454 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists
چکیده انگلیسی
A series of orexin receptor antagonists was synthesized based on a substituted piperidine scaffold. Through traditional medicinal chemistry structure-activity relationships (SAR), installation of various groups at the 3-6-positions of the piperidine led to modest enhancement in receptor selectivity. Compounds were profiled in vivo for plasma and brain levels in order to identify candidates suitable for efficacy in a model of drug addiction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 12, 15 June 2012, Pages 3890-3894
نویسندگان
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