Novel 6,7,8,9-tetrahydro-5H-1,4,7,10a-tetraaza-cyclohepta[f]indene analogues as potent and selective 5-HT2C agonists for the treatment of metabolic disorders

A new class of potent and selective 5-HT2C agonists for the treatment of metabolic disorders is described. Optimization of selectivity, permeability and hERG interaction is discussed.