کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10588631 981485 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
RNA aptazyme-tethered large gold nanoparticles for on-the-spot sensing of the aptazyme ligand
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
RNA aptazyme-tethered large gold nanoparticles for on-the-spot sensing of the aptazyme ligand
چکیده انگلیسی
A single-step sensing system was developed to visually detect ligands of a cleavase-like RNA aptazyme at room temperature using aptazyme-tethered gold nanoparticles, the electrosteric stability of which was adjusted by increasing their diameter. In this system, the ligand induces self-cleavage of the aptazyme on gold nanoparticles to decrease the electrosteric stability of the gold nanoparticles, which causes them to visibly aggregate. In comparison to a previous multi-step system using aptazymes and gold nanoparticles separately, the present system requires only single handling and no special equipment, making it more suitable for on-the-spot sensing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 1, 1 January 2011, Pages 155-159
نویسندگان
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