Design and synthesis of 3-(azol-1-yl)phenylpropanes as microbicidal spermicides for prophylactic contraception

A series of 25 3-(azol-1-yl)phenylpropanes were evaluated for spermicidal, antitrichomonas and anticandida activities. Two compounds exhibited spermicidal, antitrichomonas and anticandida activities with good safety profile, warranting further lead optimization for furnishing a prophylactic vaginal contraceptive.