کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10588691 | 981485 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata](/preview/png/10588691.png)
چکیده انگلیسی
One new licochalcone G (1) and seven known (2-8) chalcones were isolated as inhibitory principles on influenza A virus from the acetone extract of Glycyrrhiza inflata. Compounds 3 and 6 without prenyl group showed strong inhibitory effects on various neuraminidases from influenza viral strains, H1N1 and H9N2, and more novel H1N1 (WT) and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. In addition, the efficacy of oseltamivir with the presence of compound 3 (5 μM) was increased against H274Y neuraminidase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 1, 1 January 2011, Pages 294-298
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 1, 1 January 2011, Pages 294-298
نویسندگان
Trong Tuan Dao, Phi Hung Nguyen, Hong Sik Lee, Eunhee Kim, Junsoo Park, Seong Il Lim, Won Keun Oh,