کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10588783 981505 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of novel 1-phenyl-cycloalkane carbamides as potent and selective influenza fusion inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of novel 1-phenyl-cycloalkane carbamides as potent and selective influenza fusion inhibitors
چکیده انگلیسی
A novel class of HA inhibitors (4a) was identified based on ligand similarity search of known HA inhibitors. Parallel synthesis and further structural modifications resulted in 1-phenyl-cyclopentanecarboxylic acid (4-cyano-phenyl)-methyl-amide 4t as a potent and selective inhibitor to phylogenetic H1 influenza viruses with an EC50 of 98 nM against H1N1 A/Weiss/43 strain and over 1000-fold selectivity against host MDCK cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 12, 15 June 2010, Pages 3507-3510
نویسندگان
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