Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel α7 neuronal nicotinic receptor (NNR) ligands

A series of biaryl substituted 2,5-diazabicyclo[2.2.1]heptanes were synthesized as potent and selective α7 NNR agonists. Among them, compound 18e shows a α7 binding affinity of 0.2 nM.