Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: Improving metabolic stability and reducing ion channel activity

New N-(1,2-diphenylethyl)piperazines 6 are disclosed as dual serotonin and noradrenaline reuptake inhibitors (SNRI). Piperazine (−)-6a was identified as a potent and selective dual SNRI with improved metabolic stability and reduced ion channel activity when compared to previous examples.