In vivo click reaction between Tc-99m-labeled azadibenzocyclooctyne-MAMA and 2-nitroimidazole-azide for tumor hypoxia targeting

Schematic representation of tumor hypoxia-pretargeting strategy involving in vivo SPAAC reaction. Pretargeting strategy protects the bioactivity of nitroimidazole and provides innovative approach for improving the tumor hypoxia-targeting and imaging.