Synthesis and anti-HCV determinant motif identification in pyranone carboxamide scaffold

The promising candidates with average mol. wt. ∼ 350 and c log P ∼ 2.7 identified with ±0.5 μM of EC50 in cell based HCV replicon system. The -NHOH motif identification as activity determinant cliff in pyranone carboxamide scaffold I.