Halogenated diarylacetylenes repress c-myc expression in cancer cells

Halogenated diarylacetylenes 2 (X1-5 = H, F and/or Cl and Y = 4-NHCH3 or 4-N(CH3)2) inhibit that inhibit the expression of Wnt target genes, such as c-myc, at 1-3 μM concentrations and induce the cyclin-dependent kinase inhibitor-1 (i.e., p21(Wif1/Cip1)).