Discovery of cyantraniliprole, a potent and selective anthranilic diamide ryanodine receptor activator with cross-spectrum insecticidal activity

This Letter describes the chemistry and structure-activity trends for a series of cyanoanthranilic diamides that exhibit their insecticidal action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. From this work, cyantraniliprole was selected for commercial development.