Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold

Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 25, Issue 2, 15 January 2015, Pages 367-371

Yan Lou, Zachary K. Sweeney, Andreas Kuglstatter, Dana Davis, David M. Goldstein, Xiaochun Han, Junbae Hong, Buelent Kocer, Rama K. Kondru, Renee Litman, Joel McIntosh, Keshab Sarma, Judy Suh, Joshua Taygerly, Timothy D. Owens,