کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10591771 | 981761 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, antimicrobial and molecular docking studies of enantiomerically pure N-alkylated β-amino alcohols from phenylpropanolamines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Enantiomerically pure N-alkylated β-amino alcohols 1a, 1aâ², 1c, 1câ², 1d, 1dâ², 1e and 1eâ², with ee 100% have been synthesized from phenylpropanolamines 2. Effect of the neighboring chiral environment on the newly formed chiral center has been studied experimentally and concluded that the newly formed chiral center's absolute configuration is opposite to the adjacent (α- or β-) chiral environment. The antimicrobial activity of the synthesized β-amino alcohols were screened using in vitro disc diffusion method and variable antimicrobial activities were shown for 1a, 1aâ², 1c, 1câ², 1d, 1dâ², 1e & 1eâ² and amongst them 1d & 1dâ² exhibited significant activity against bacteria and fungi. In silico studies revealed all the synthesized β-amino alcohols 1a-e and 1aâ²-eâ² have shown good binding energies ranging from â7.38 to â6.09 kJ/mol towards the target receptor DNA topoisomerase IV and 1dâ² has shown maximum binding energy â7.38 kJ/mol.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 14, 15 July 2014, Pages 3057-3063
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 14, 15 July 2014, Pages 3057-3063
نویسندگان
K. Chennakesava Rao, Y. Arun, K. Easwaramoorthi, C. Balachandran, T. Prakasam, T. Eswara Yuvaraj, P.T. Perumal,