Marine spongian sesquiterpene phenols, dictyoceratin-C and smenospondiol, display hypoxia-selective growth inhibition against cancer cells

Marine spongian sesquiterpene phenols, dictyoceratin-C (1) and smenospondiol (2), selectively inhibited proliferation of cancer cells under hypoxic condition, through preventing accumulation of Hypoxia-Inducible Factor-1α.