کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10591894 981769 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of a synthetic Aminopeptidase N inhibitor LB-4b as a potential anticancer agent
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of a synthetic Aminopeptidase N inhibitor LB-4b as a potential anticancer agent
چکیده انگلیسی
APN inhibitors have been considered as potential anticancer agents for years. LB-4b is the first synthetic APN inhibitor to be evaluated for both of its anti-invasion and anti-angiogenesis effects. As a potent synthetic APN inhibitor (IC50 = 850 nM, versus bestatin of 8.1 μM), LB-4b was determined to have more significant block effects to cancer cell invasion and angiogenesis than bestatin. Besides, it is able to be easily synthesized with a high total yield, while the reported synthetic methods of bestatin are much more complex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 9, 1 May 2013, Pages 2512-2517
نویسندگان
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