Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors

Studies of the in vitro vascular properties of 4-(arylmethoxy)-1-alkylpiperidine inhibitors of the dopamine transporter are reported. The lipophilicity given by the size of the N-aryl substituent potentiated the inhibitory effect with 4a being the most effective blocker of KCl and noradrenaline-induced contractions.