1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile

1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 25, Issue 24, 15 December 2015, Pages 5720-5725

Hazel J. Hunt, Joseph K. Belanoff, Emily Golding, Benoit Gourdet, Timothy Phillips, Denise Swift, Jennifer Thomas, John F. Unitt, Iain Walters,