Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA

Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 12, 15 June 2016, Pages 2817-2820

Thazha P. Prakash, Garth A. Kinberger, Heather M. Murray, Alfred Chappell, Stan Riney, Mark J. Graham, Walt F. Lima, Eric E. Swayze, Punit P. Seth,