Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency

Based on the binding mode of quinolones with HCV NS5B, 2-alkyl-N-arylquinolones and 1,6-naphthyridine-4,5-diones were designed and discovered as novel HCV inhibitors with submicromolar cellular replican potency.105