Discovery of novel (1S)-(−)-verbenone derivatives with anti-oxidant and anti-ischemic effects

Novel (1S)-(−)-verbenone derivatives were synthesized with antioxidant/anti-excitotoxic activities and examined for anti-ischemic activities. Compound 3f exhibited potent anti-oxidant/anti-excitotoxic activities and showed potent anti-ischemic activity in an in vitro ischemic model.