کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10593248 981804 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens
چکیده انگلیسی
A novel series of acylides 4 were designed to overcome antibacterial resistance and evaluated for in vitro and in vivo activity. This series of acylides was designed from clarithromycin by changing the substitution on the desosamine nitrogen, followed by conversion to 3-O-acyl and 11,12-carbamate. These compounds showed significantly potent antibacterial activity against not only Gram-positive pathogens, including macrolide-lincosamide-streptogramin B (MLSB)-resistant and efflux-resistant strains, but also Gram-negative pathogens such as Haemophilus influenzae. These acylides also showed better activity against telithromycin resistant Streptococcus pneumoniae strains.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 1, 1 January 2012, Pages 476-481
نویسندگان
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