کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10593477 | 981808 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-κB activation and PPAR transcriptional activity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Three new diarylheptanoid glycosides, plantagineosides A-C (1-3), and three known compounds (4-6) were isolated from the whole plant of Tacca plantaginea. Compounds 3-6 significantly inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells with IC50 values ranging from 0.9 to 9.4 μM. Compounds 1-6 significantly activated the transcriptional activity of PPARs with EC50 values ranging from 0.30 to 10.4 μM. In addition, the transactivational effects of compounds 1-6 were evaluated on three individual PPAR subtypes, including PPARα, γ, and β(δ).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 21, 1 November 2012, Pages 6681-6687
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 21, 1 November 2012, Pages 6681-6687
نویسندگان
Tran Hong Quang, Nguyen Thi Thanh Ngan, Chau Van Minh, Phan Van Kiem, Pham Hai Yen, Bui Huu Tai, Nguyen Xuan Nhiem, Nguyen Phuong Thao, Hoang Le Tuan Anh, Bui Thi Thuy Luyen, Seo Young Yang, Chun Whan Choi, Young Ho Kim,