کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10593477 981808 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-κB activation and PPAR transcriptional activity
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-κB activation and PPAR transcriptional activity
چکیده انگلیسی
Three new diarylheptanoid glycosides, plantagineosides A-C (1-3), and three known compounds (4-6) were isolated from the whole plant of Tacca plantaginea. Compounds 3-6 significantly inhibited TNFα-induced NF-κB transcriptional activity in HepG2 cells with IC50 values ranging from 0.9 to 9.4 μM. Compounds 1-6 significantly activated the transcriptional activity of PPARs with EC50 values ranging from 0.30 to 10.4 μM. In addition, the transactivational effects of compounds 1-6 were evaluated on three individual PPAR subtypes, including PPARα, γ, and β(δ).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 21, 1 November 2012, Pages 6681-6687
نویسندگان
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