کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10593750 981813 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs
چکیده انگلیسی
A series of analogs of DM235 and MN19, characterized by rings with different size, have been prepared and evaluated for their nootropic activity in the mouse passive-avoidance test. It was found that the optimal ring size for the analogs of DM235, showing endocyclic both amidic groups, is 6 or 7 atoms. For the compounds structurally related to MN19, carrying an exocyclic amide group, the piperidine ring is the moiety which gives the most interesting compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 5, 1 March 2012, Pages 1936-1939
نویسندگان
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