کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10593829 | 981813 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Adamantyl N-benzylbenzamide: New series of depigmentation agents with tyrosinase inhibitory activity
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Adamantyl N-benzylbenzamide: New series of depigmentation agents with tyrosinase inhibitory activity Adamantyl N-benzylbenzamide: New series of depigmentation agents with tyrosinase inhibitory activity](/preview/png/10593829.png)
چکیده انگلیسی
A new series of polyhydroxylated N-benzylbenzamide derivatives containing an adamantyl moiety has been synthesized, and the depigmenting and tyrosinase inhibitory activities of the molecules were evaluated. The lipophilic character of the adamantyl moiety appeared to confer greater depigmentation power on the benzamide derivatives as compared to those lacking adamantyl substitution. Molecular modeling was applied in order to elucidate the interactions between ligands and tyrosinase that led to inhibition.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 5, 1 March 2012, Pages 2110-2113
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 5, 1 March 2012, Pages 2110-2113
نویسندگان
Heung Soo Baek, Yong Deog Hong, Chang Seok Lee, Ho Sik Rho, Song Seok Shin, Young-Ho Park, Yung Hyup Joo,