Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor

A series of 7-aminopyrazolo[1,5-a]pyrimidine (7-APP) derivatives was screened via phenotypic cell-based assay. Among the compounds tested, compound 32 turned out to be the most promising with 0.28 μM EC50 value in the infectious HCVcc.