کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10594181 981821 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of 99mTc(CO)3(His-CB) as a tumor imaging agent
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of 99mTc(CO)3(His-CB) as a tumor imaging agent
چکیده انگلیسی
The chlorambucil l-histidine conjugate was synthesized and radiolabeled with [99mTc(CO)3]+ core to form the 99mTc(CO)3(His-CB) complex. The radiochemical purity of the complex was over 90%. It had good hydrophilicity and was stable at room temperature. The high initial tumor uptake with certain retention, fast clearance from background, good tumor/non-tumor ratios and satisfactory scintigraphic images highlighted the potential of 99mTc(CO)3(His-CB) as a tumor imaging agent.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 24, 15 December 2012, Pages 7406-7409
نویسندگان
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