Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate

A novel gastro-sparing prodrug of rhein and boswellic acid was designed for the management of osteoarthritis and its synthesis, characterization and pharmacokinetic profile is reported. The prodrug was activated by hydrolysis releasing rhein (91%) and boswellic acid (84.37%) in rat blood over a period of 7 h upon its oral administration.