کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10594257 981821 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Uronosyl phosphonate-based sialidase inhibitor synthesis and conformational analysis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Uronosyl phosphonate-based sialidase inhibitor synthesis and conformational analysis
چکیده انگلیسی
With a view to development of novel sialidase inhibitors, mimetics of the natural inhibitor Neu5Ac2en have been prepared in which a phosphonate group replaces the sialic acid glycerol side chain. Different hex-4-en derivatives adopt half-chair conformations that place the glycosyl phosphonate in an equatorial position. For the α-L-threo-hex-4-en derivative this conformation is equivalent to that of Neu5Ac2en, and opposite to that seen for alkyl O-glycosides with the same overall stereochemistry.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 24, 15 December 2012, Pages 7623-7626
نویسندگان
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