Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1)

The design, syntheses and structure-activity relationships (SAR) of novel zwitterionic compounds as non-thiazolidinedion (TZD) based peroxisome proliferator activated receptor (PPAR) α/γ dual agonists are described. Compound 22e showed a highly potent dual agonist activity, together with a great glucose lowering effect without body weight gain in vivo model.