کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10594367 | 981826 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities](/preview/png/10594367.png)
چکیده انگلیسی
Emergence of bacterial resistance has eroded the effectiveness of many life saving antibiotics leading to an urgent need for new chemical classes of antibacterial agents. We have applied a Staphylococcus aureus fitness test strategy to natural products screening to meet this challenge. In this paper we report the discovery of kibdelomycin A, a demethylated congener of kibdelomycin, the representative of a novel class of antibiotics produced by a new strain of Kibdelosporangium. Kibdelomycin A is a potent inhibitor of DNA gyrase and topoisomerase IV, inhibits DNA synthesis and shows whole cell antibiotic activity, albeit, less potently than kibdelomycin. Kibdelomycin C-33 acetate and tetrahydro-bisdechloro derivatives of kibdelomycin were prepared which helped define a basic SAR of the family.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 23, 1 December 2012, Pages 7127-7130
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 23, 1 December 2012, Pages 7127-7130
نویسندگان
Sheo B. Singh, Michael A. Goetz, Scott K. Smith, Deborah L. Zink, Jon Polishook, Russell Onishi, Scott Salowe, Judyann Wiltsie, John Allocco, Janet Sigmund, Karen Dorso, Mercedes de la Cruz, Jesús MartÃn, Francisca Vicente, Olga Genilloud,