کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10594500 | 981831 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antituberculosis activity of novel unfolded and macrocyclic derivatives of ent-kaurane steviol
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and antituberculosis activity of novel unfolded and macrocyclic derivatives of ent-kaurane steviol Synthesis and antituberculosis activity of novel unfolded and macrocyclic derivatives of ent-kaurane steviol](/preview/png/10594500.png)
چکیده انگلیسی
New derivatives of steviol 1, the aglycone of the glycosides of Stevia rebaudiana, including a novel class of semisynthetic diterpenoids, namely macrocyclic ent-kauranes were synthesized. These compounds possess antituberculosis activity inhibiting the in vitro growth of Mycobacterium Tuberculosis (H37RV strain) with MIC 5-20 μg/ml that is close to MIC 1 μg/ml demonstrated by antituberculosis drug isoniazid in control experiment. For the first time it was found that the change of ent-kaurane geometry (as in steviol 1) of tetracyclic diterpenoid skeleton to ent-beyerane one (as in isosteviol 2) influences on antituberculosis activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 22, 15 November 2012, Pages 6909-6913
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 22, 15 November 2012, Pages 6909-6913
نویسندگان
Ravil N. Khaybullin, Irina Yu. Strobykina, Alexey B. Dobrynin, Aidar T. Gubaydullin, Regina V. Chestnova, Vasiliy M. Babaev, Vladimir E. Kataev,