A modified synthesis and serological evaluation of neoglycoproteins containing the natural disaccharide of PGL-I from Mycobacterium leprae

The non-reducing disaccharide segment of phenolic glycolipid I from Mycobacterium leprae, O-(3,6-di-O-methyl-β-d-glucopyranosyl)-(1→4)-O-2,3-di-O-methyl-α-l-rhamnopyranose was synthesized by an improved procedure and efficiently conjugated to bovine/human serum albumin.