Discovery of bis-aromatic ring neonicotinoid analogues fixed as cis-configuration: Synthesis, insecticidal activities, and molecular docking studies

A new series of bis-aromatic ring neonicotinoid analogues (1a-1l, 2a-2c) were prepared and evaluated for their insecticidal activities. Modeling the ligand-receptor complexes by molecular docking explained the structure-activity relationships observed in vitro.