کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10594808 | 981852 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin® Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®](/preview/png/10594808.png)
چکیده انگلیسی
β-Lactamase inhibitors with a bicyclic urea core and a variety of heterocyclic side chains were prepared and evaluated as potential partners for combination with imipenem to overcome class A and C β-lactamase mediated antibiotic resistance. The piperidine analog 3 (MK-7655) inhibited both class A and C β-lactamases in vitro. It effectively restored imipenem's activity against imipenem-resistant Pseudomonas and Klebsiella strains at clinically achievable concentrations. A combination of MK-7655 and Primaxin® is currently in phase II clinical trials for the treatment of Gram-negative bacterial infections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 3, 1 February 2014, Pages 780-785
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 3, 1 February 2014, Pages 780-785
نویسندگان
Timothy A. Blizzard, Helen Chen, Seongkon Kim, Jane Wu, Rena Bodner, Candido Gude, Jason Imbriglio, Katherine Young, Young-Whan Park, Aimie Ogawa, Susan Raghoobar, Nichelle Hairston, Ronald E. Painter, Doug Wisniewski, Giovanna Scapin, Paula Fitzgerald,