کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10594844 981852 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biological evaluation of new antitumor taxoids: Alteration of substitution at the C-7 and C-10 of docetaxel
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Biological evaluation of new antitumor taxoids: Alteration of substitution at the C-7 and C-10 of docetaxel
چکیده انگلیسی
A series of new docetaxol analogues have been designed and synthesized. And their cytotoxicities against cancer cells have been evaluated by MTT method. Most of these compounds showed selective inhibitions on human cancer cell lines. Among them, compound 8 exhibited higher inhibitory activity than Paclitaxel (Taxol) against several cancer cell lines. This work indicated that appropriate modification at C-7 and C-10 of docetaxel might be a promising approach for this unique class of anticancer compounds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 3, 1 February 2014, Pages 855-859
نویسندگان
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