Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation

The identification of 2-amino-N-((S)-1-(2-(hydroxyamino)-2-oxoethyl)-2,5-dioxopyrrolidin-3-yl)-3-phenylpropanamide as a potent inhibitor of aminopeptidase N is reported.