کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10595180 981861 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP
چکیده انگلیسی
C-di-GMP has emerged as an important bacterial signaling molecule that is involved in biofilm formation. Small molecules that can form biologically inactive complexes with c-di-GMP have the potential to be used as anti-biofilm agents. Herein, we report that water-soluble diamidinium/iminium aromatics (such as berenil), which are traditionally considered as minor groove binders of nucleic acids, are capable of aggregating c-di-GMP into G-quadruplexes via π-stacking interactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 2, 15 January 2012, Pages 881-885
نویسندگان
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