کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10595517 981873 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and anticancer activity of dichloroplatinum(II) complexes of podophyllotoxin
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and anticancer activity of dichloroplatinum(II) complexes of podophyllotoxin
چکیده انگلیسی
A series of dichloroplatinum(II) complexes of podophyllotoxin (PPT) were prepared, and their cytotoxicity against sensitive (A-549, HeLa, HCT-8, Hep-G2, K562) and resistant (ADM/K562) cell lines were evaluated. Complex cis-[4α-O-(2″,3″-diaminopropanoyl)-podophyllotoxin] dichloride platinum(II) (12) displayed most potent cytotoxicity with IC50 value in the range 0.071-2.98 μM. Complex 12 induces cell cycle arrest in the G2/M phase, and inhibits the formation of microtubules in HeLa cells. Furthermore, this complex exhibits potent DNA cleavage capabilities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 13, 1 July 2013, Pages 3780-3784
نویسندگان
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