کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10595553 981873 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Membrane anchoring γ-secretase modulators with terpene-derived moieties
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Membrane anchoring γ-secretase modulators with terpene-derived moieties
چکیده انگلیسی
Modulation of γ-secretase activity is a promising therapeutic strategy for the treatment of Alzheimer's disease. Herein we report on the synthesis of carprofen- and tocopherol-derived small-molecule modulators carrying terpene moieties as lipophilic membrane anchors. Additionally, these modulators are equipped with an acidic moiety, which contributes to the desired modulatory effect on the γ-secretase with decreased formation of Aβ42 and increased Aβ38 production.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 13, 1 July 2013, Pages 3852-3856
نویسندگان
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