کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10595845 981877 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators
چکیده انگلیسی
Glycogen synthase (GS) catalyzes the transfer of glucose residues from UDP-glucose to a glycogen polymer chain, a critical step for glucose storage. Patients with type 2 diabetes normally exhibit low glycogen levels and decreased muscle glucose uptake is the major defect in whole body glucose disposal. Therefore, activating GS may provide a potential approach for the treatment of type 2 diabetes. In order to identify non-carboxylic acids GS activators, we designed and synthesized a series of 2-N-alkyl- and 2-N-aryl-indazolone derivatives and studied their activity in activating human GS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 10, 15 May 2013, Pages 2936-2940
نویسندگان
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