کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10595870 981877 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives
چکیده انگلیسی
A novel series of amide derivatives of lomefloxacin were synthesized and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against a panel of five human cancer cell lines. Of the compounds prepared compounds 9d and 9g exhibited strong inhibition against topoisomerase II at 100 μM. In addition, docking studies were performed to predict the inhibition mode.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 10, 15 May 2013, Pages 2974-2978
نویسندگان
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