Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells

This Letter describes the synthesis and biological evaluation of a collection of aminophthalazines capable of reducing PGE2 production in HCA-7 colon cancer cells. A total of twenty eight analogs were tested and active compounds were identified. Furthermore, the anti-tumor activity of analog 2vii was analyzed in xenograft mouse models demonstrating promising anti-cancer activity.