Anti-inflammatory norditerpenoids from the soft coral Sinularia maxima

Two new norditerpenoids, 12-hydroxy-scabrolide A (2), 13-epi-scabrolide C (6) and five know compounds (1, 3-5, 7) were isolated from the methanol extract of the soft coral Sinularia maxima. They were evaluated for inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs). Compound 6 potently inhibited IL-12 and IL-6 production in LPS-stimulated bone marrow derived dendritic with IC50 values ranging from 5.30 ± 0.21 to 13.12 ± 0.64 μM. Compound 1 exhibited moderate inhibitory activity against IL-12 and IL-6 production with IC50 values ranging from 23.52 ± 1.37 to 69.85 ± 4.11 μM.