کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10596494 981902 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exploring converse molecular mechanisms of anti-HIV-1 antibodies using a synthetic CXCR4 mimic
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Exploring converse molecular mechanisms of anti-HIV-1 antibodies using a synthetic CXCR4 mimic
چکیده انگلیسی
Different molecular mechanisms of the two broadly neutralizing anti-HIV-1 antibodies b12 and VRC01, as evidenced by their converse effects on the interaction of HIV-1 envelope glycoprotein gp120 with cellular coreceptors, were demonstrated using a synthetic CXCR4 mimetic peptide (CX4-M1) as coreceptor surrogate. While the interaction of gp120 with CX4-M1 was distinctly enhanced by VRC01, b12 was shown to have the contrary effect, and also to inhibit the VRC01-induced enhancement of gp120 binding to the CXCR4 mimetic peptide.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 19, 1 October 2012, Pages 6099-6102
نویسندگان
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