10-23 DNAzyme modified with (2′R)- and (2′S)-2′-deoxy-2′-C-methyluridine in the catalytic core

2′-Deoxy-2′-C-methyl nucleosides were incorporated at T positions of the catalytic core of a 10-23 DNAzyme directed against estrogen receptor α ARNm. Comparison against DNAzymes modified with LNA-T was also performed.