کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10596877 | 981953 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Studies on synthesis and evaluation of quantitative structure-activity relationship of 5-[(3â²-chloro-4â²,4â²-disubstituted-2-oxoazetidinyl)(N-nitro)amino]-6-hydroxy-3-alkyl/aryl[1,3]azaphospholo[1,5-a]pyridin-1-yl-phosphorus dichlorides
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Studies on synthesis and evaluation of quantitative structure-activity relationship of 5-[(3â²-chloro-4â²,4â²-disubstituted-2-oxoazetidinyl)(N-nitro)amino]-6-hydroxy-3-alkyl/aryl[1,3]azaphospholo[1,5-a]pyridin-1-yl-phosphorus dichlorides Studies on synthesis and evaluation of quantitative structure-activity relationship of 5-[(3â²-chloro-4â²,4â²-disubstituted-2-oxoazetidinyl)(N-nitro)amino]-6-hydroxy-3-alkyl/aryl[1,3]azaphospholo[1,5-a]pyridin-1-yl-phosphorus dichlorides](/preview/png/10596877.png)
چکیده انگلیسی
A new series of 5-[(3â²-chloro-4â²,4â²-disubstituted-2-oxoazetidinyl)(N-nitro)amino]-6-hydroxy-3-alkyl/aryl[1,3]azaphospholo[1,5-a]pyridin-1-yl-phosphorus dichlorides has been synthesized and subjected to acute antibacterial and antifungal screening studies. All the derivatives belonging to this series delineated remarkable activity as compared to standard drugs (ampicillin and clotrimazole). Compounds are quantitatively analyzed in relation to their different physicochemical parameters. Significant correlations were obtained between biological activity and polarizability parameter MR. Apart from this, indicator variables had also played a significant role.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 4, 15 February 2005, Pages 937-943
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 4, 15 February 2005, Pages 937-943
نویسندگان
Pratibha Sharma, Ashok Kumar, Shikha Sharma, Nilesh Rane,